Press Releases

STOCKHOLM. Umecrine Cognition AB, a Karolinska Development (NASDAQ Stockholm: KDEV) portfolio company, today announced that the United States Patent and Trademark Office (USPTO) has issued a Notice of Allowance for a patent protecting a pharmaceutical formulation of its lead candidate drug golexanolone, currently in clinical Phase 2a development for hepatic encephalopathy. Upon issuance, the granted patent will expire in 2038.

STOCKHOLM. Umecrine Cognition AB, a Karolinska Development (Nasdaq Stockholm: KDEV) portfolio company, today announced that enrollment has been completed in its Phase 2a study designed to assess the safety, pharmacokinetics and potential benefit of golexanolone, a novel GABAA receptor modulating steroid antagonists, in development for treatment of Hepatic Encephalopathy (HE) in patients with liver cirrhosis.

STOCKHOLM. Umecrine Cognition AB, a Karolinska Development (Nasdaq Stockholm: KDEV) portfolio company, today announced enrollment of the first patient in the final part of a Phase 2a study designed to assess the safety, pharmacokinetics and potential benefit of GR3027, a novel GABAA receptor modulating steroid antagonists (GAMSA), under development for treatment of Hepatic Encephalopathy (HE).

STOCKHOLM/UMEÅ. Umecrine Cognition today reports results from a phase 2a study of GR3027 – a first-in-class drug candidate being developed as a potential new treatment for a range of CNS-related disorders. The primary study objectives were met in regard to safety and pharmacokinetics. The study also showed preliminary evidence of clinical efficacy in a subset of patients, but the data needs to be further analyzed before a decision to potentially move forward with the development of GR3027 in idiopathic hypersomnia or other sleep disorders. In parallel, Umecrine Cognition will continue the clinical development in hepatic encephalopathy.